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Latest Research

We work with advisors and allied professionals to participate in the latest research in symptomatic hypermobility and neurodivergence. 

"I hear you". Validation in the context of children's pain as an untapped opportunity to prevent chronic pain

Wallwork, Sarah B.; Shenk, Chadb,c; McMurtry, C. Meghand; Hood, Anna M.e; Pavlova, Mariaf; Olson, Anneke E.b; Moseley, G. Lorimera; Noel, Melanieg

PAIN: The Journal of the International Association journal for the Study of Pain.​​

Subscriber only, no abstract available. Read more.

Nutritional Considerations for Hypermobile Ehlers-Danlos Syndrome

Cheryl Iny Harris, Dacre R.T. Knight, Lisa A. Mejia, Laurie Bilyeu

While the hallmarks of hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum
disorders (HSD) are pain, joint instability, and injuries to soft tissues, most patients with hEDS and
HSD have a myriad of manifestations within the gastrointestinal tract that affect dietary tolerance
and quality of life. 

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Correlation between attention deficit/hyperactivity disorder and chronic pain: a survey of adults in Japan

Satoshi Kasahara, Takahiko Yoshimoto, Hiroyuki Oka, Naoko Sato, Taito Morita, Shin-Ichi Niwa, Kanji Uchida, Ko Matsudaira

This cross-sectional epidemiological internet survey assessed whether attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) symptoms are associated with pain chronicity and intensity and explored the relationship between developmental disorder symptoms and pain. Participants were 4028 adults aged 20–64 years who experienced pain, assessed using an 11-point numerical rating scale (NRS), in any body part in the previous 4 weeks. ADHD and ASD symptoms were assessed using the Adult ADHD Self-Report Scale (ASRS) and autism spectrum quotient, respectively. 

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Gastrointestinal Manifestations of hEDS/HSD

Laura Brockway, Specialist Nurse

T

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Sleep disorders in patients with postural tachycardia syndrome: A review of the literature and guide for clinicians

Mitchell G. Miglisa, Fiona Barwick

Fatigue is common in POTS, and patients often report unrefreshing sleep. These symptoms are directly correlated with a reduced quality of life, however the treatment of sleep disorders in this population remains a challenge. This article will review the current literature on the prevalence of sleep disorders in POTS, their association with the underlying pathophysiology of POTS, and current treatment paradigms.

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Correlation between benign joint hypermobility syndrome and headache in children and adolescents

Mohsen Jari & Sogol Alesaeidi

Benign Joint Hypermobility Syndrome (BJHS) is a most common hereditary connective tissue disorders in children and adolescents. This study aimed to investigate the prevalence and subtypes of headache in children with BJHS.

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Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain

Cheryl Iny Harris, Dacre R.T. Knight, Lisa A. Mejia, Laurie Bilyeu



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Is joint hypermobility linked to self reported non-recovery from COVID-19? COVID Symptom Study Biobank 2024

Jessica A Eccles, Dorina Cadar, Lisa Quadt, Alan J Hakim, Nicholas Gall; Covid Symptom Survey Biobank Consortium, Vicky Bowyer, Nathan Cheetham, Claire J Steves, Hugo D Critchle, Kevin A Davies

This results show that if you have connective tissue differences (GJH) you are 30% less likely to recover from Covid. 

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Co-Occurring Physical Health Challenges in Neurodivergent Children and Young People: A Topical Review and Recommendation

Bethany Donagh, David Moore & Jane Green

A topical review peer review. Neurodivergence has been established as associated with a significant number of co-occurring physical conditions, particularly for autistic individuals who are at risk for increased pain, hypermobility  fatigue and gastrointestinal problems. However, data, so far, has been focused on adults and generally limited to discussions of condition prevalence alone.

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A model linking emotional dysregulation in neurodivergent people to the proprioceptive impact of joint hypermobility (2024)

Jessica A. Eccles, Lisa Quadt, Sarah N. Garfinkel and Hugo D. Critchley



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Do people with M.E./CFS and joint hypermobility represent a disease subgroup? An analysis using registry data.

Allison Ramiller, Sadie Whittaker, Leslie E. Phillips

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, multifaceted disease that affects millions globally. Despite its significant impact, the disease's etiology remains poorly understood, and symptom heterogeneity poses challenges for diagnosis and treatment. Joint hypermobility, commonly seen in hypermobile Ehlers-Danlos Syndrome (hEDS), has been observed in ME/CFS patients but its prevalence and clinical significance within this population are not well-characterized.

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Misophonia reactions in the general population are correlated with strong emotional reactions to other everyday sensory–emotional experiences (2024)

Solena D. Mednicoff, Sivan Barashy, David J. Vollweiler, Stephen D. Benning, Joel S. Snyder and Erin E. Hannon

Misophonic experiences are common in the general population, and they may shed light on everyday emotional reactions to multi-modal stimuli. We performed an online study of a non-clinical sample to understand the extent to which adults who have misophonic reactions are generally reactive to a range of audio-visual emotion-inducing stimuli. 

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Variant connective tissue (joint hypermobility) and its relevance to depression and anxiety in adolescents: a cohort-based case–control study.​

Jessica A Eccles, Lisa Quadt, Hannah McCarthy, Kevin A Davies, Rod Bond, Anthony S David, Neil A Harrison, Hugo D Critchley

To test whether variant connective tissue structure, as indicated by the presence of joint hypermobility, poses a developmental risk for mood disorders in adolescence.

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Tourette syndrome associated with attention deficit hyperactivity disorder: The impact of tics and psychopharmacological treatment options

Jenny L L Csecs, Valeria Iodice, Charlotte L Rae, Alice Brooke, Rebecca Simmons, Lisa Quadt, Georgia K Savage, Nicholas G Dowell, Fenella Prowse, Kristy Themelis, Christopher J Mathias, Hugo D Critchley, Jessica A Eccles



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